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Assessment of COVID-19 Cases by Haematological and Biochemical Markers: A Tertiary Care Hospital Study in Dhaka, Bangladesh

Received: 13 September 2021     Accepted: 12 October 2021     Published: 29 October 2021
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Abstract

Background: On 8 March 2020 the first COVID-19 case was detected in Bangladesh. Day by day this disease is changing its own nature and dimension. So, it is very difficult to define the exact risk factors associated with such ferocious diseases. In this situation, haematological and biochemical analysis of COVID-19 patients may play an important role in the current and future planning of COVID treatment. Aim of the study: The aim of this study was to assess the COVID-19 status of Covid patients by haematological and biochemical markers. Materials and Methods: This prospective observational study was conducted among 350 participants who attended the Bashundhara Ad-Din Medical College Hospital, Hasnabad, South Keranigonj, Dhaka, Bangladesh after confirmation by RT-PCR. Using 5 ml fasting venous blood samples different haematological and biochemical biomarkers were analyzed. These were analyzed in auto analysis using a standard protocol as per the manufacturer’s instructions. Finally, results were analyzed using standard statistical calculation by% positivity, confidence interval, p values where p≤0.05 was considered as statistically significant. Results: In this study, in critical participant group, the mean (±SD) HBC, RBC, TLC, PCV, NLR, Platelet Counts, SGOT and SGPT were found 11.56±2.07, 3.64±2.82, 12372±2920, 29.17±7.84, 2.8±0.32, 98743±32127, 67.91±31.54 and 71.39±33.74 respectively. On the other hand, in non-critical patient group those reading were found 12.78±2.17, 4.02±2.90, 10956±2744, 35.03±8.22, 2.7±0.28, 129544±51228, 65.68±27.96 and 67.55±26.57 respectively. In analyzing the haematological and biochemical parameters among participants we found ‘extremely significant correlations’ between critical and non-critical groups in HBC, TLC, PCV, Platelet Counts, S. Creatinine and D-Dimer test results where p values were <0.0001. On the other hand, we found only ‘significant correlation’ between critical and non-critical groups in NLR, CRP, Serum Ferritin and LDH test results where the p values were <0.05. The average age of the total participants was 47.27±14.66 years. In the critical group, it was 54.19±15.23 and in the non-critical group, it was 43.03±13.68 years. So, the mean age of critical patients was higher than that of non-critical patients. Conclusion: Haematological and biochemical markers may be considered as the most potential parameters in assessing the severity of COVID-19 infection. But, advanced training required for laboratory personnel’s who are responsible for collecting, transporting and handling biological samples and carrying out the various laboratory tests for patients with COVID-19 is recommended.

Published in European Journal of Preventive Medicine (Volume 9, Issue 5)
DOI 10.11648/j.ejpm.20210905.14
Page(s) 133-139
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

COVID-19, SARS-CoV-2, Haematological, Biochemical Markers, Bangladesh

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Cite This Article
  • APA Style

    Sanjoy Kumar Saha, Md. Nuruzzaman, Sajalendu Biswas, Amitav Saha, Mohammad Obayedur Rahman, et al. (2021). Assessment of COVID-19 Cases by Haematological and Biochemical Markers: A Tertiary Care Hospital Study in Dhaka, Bangladesh. European Journal of Preventive Medicine, 9(5), 133-139. https://doi.org/10.11648/j.ejpm.20210905.14

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    ACS Style

    Sanjoy Kumar Saha; Md. Nuruzzaman; Sajalendu Biswas; Amitav Saha; Mohammad Obayedur Rahman, et al. Assessment of COVID-19 Cases by Haematological and Biochemical Markers: A Tertiary Care Hospital Study in Dhaka, Bangladesh. Eur. J. Prev. Med. 2021, 9(5), 133-139. doi: 10.11648/j.ejpm.20210905.14

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    AMA Style

    Sanjoy Kumar Saha, Md. Nuruzzaman, Sajalendu Biswas, Amitav Saha, Mohammad Obayedur Rahman, et al. Assessment of COVID-19 Cases by Haematological and Biochemical Markers: A Tertiary Care Hospital Study in Dhaka, Bangladesh. Eur J Prev Med. 2021;9(5):133-139. doi: 10.11648/j.ejpm.20210905.14

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  • @article{10.11648/j.ejpm.20210905.14,
      author = {Sanjoy Kumar Saha and Md. Nuruzzaman and Sajalendu Biswas and Amitav Saha and Mohammad Obayedur Rahman and Mohammad Asaduzzaman},
      title = {Assessment of COVID-19 Cases by Haematological and Biochemical Markers: A Tertiary Care Hospital Study in Dhaka, Bangladesh},
      journal = {European Journal of Preventive Medicine},
      volume = {9},
      number = {5},
      pages = {133-139},
      doi = {10.11648/j.ejpm.20210905.14},
      url = {https://doi.org/10.11648/j.ejpm.20210905.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejpm.20210905.14},
      abstract = {Background: On 8 March 2020 the first COVID-19 case was detected in Bangladesh. Day by day this disease is changing its own nature and dimension. So, it is very difficult to define the exact risk factors associated with such ferocious diseases. In this situation, haematological and biochemical analysis of COVID-19 patients may play an important role in the current and future planning of COVID treatment. Aim of the study: The aim of this study was to assess the COVID-19 status of Covid patients by haematological and biochemical markers. Materials and Methods: This prospective observational study was conducted among 350 participants who attended the Bashundhara Ad-Din Medical College Hospital, Hasnabad, South Keranigonj, Dhaka, Bangladesh after confirmation by RT-PCR. Using 5 ml fasting venous blood samples different haematological and biochemical biomarkers were analyzed. These were analyzed in auto analysis using a standard protocol as per the manufacturer’s instructions. Finally, results were analyzed using standard statistical calculation by% positivity, confidence interval, p values where p≤0.05 was considered as statistically significant. Results: In this study, in critical participant group, the mean (±SD) HBC, RBC, TLC, PCV, NLR, Platelet Counts, SGOT and SGPT were found 11.56±2.07, 3.64±2.82, 12372±2920, 29.17±7.84, 2.8±0.32, 98743±32127, 67.91±31.54 and 71.39±33.74 respectively. On the other hand, in non-critical patient group those reading were found 12.78±2.17, 4.02±2.90, 10956±2744, 35.03±8.22, 2.7±0.28, 129544±51228, 65.68±27.96 and 67.55±26.57 respectively. In analyzing the haematological and biochemical parameters among participants we found ‘extremely significant correlations’ between critical and non-critical groups in HBC, TLC, PCV, Platelet Counts, S. Creatinine and D-Dimer test results where p values were Conclusion: Haematological and biochemical markers may be considered as the most potential parameters in assessing the severity of COVID-19 infection. But, advanced training required for laboratory personnel’s who are responsible for collecting, transporting and handling biological samples and carrying out the various laboratory tests for patients with COVID-19 is recommended.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Assessment of COVID-19 Cases by Haematological and Biochemical Markers: A Tertiary Care Hospital Study in Dhaka, Bangladesh
    AU  - Sanjoy Kumar Saha
    AU  - Md. Nuruzzaman
    AU  - Sajalendu Biswas
    AU  - Amitav Saha
    AU  - Mohammad Obayedur Rahman
    AU  - Mohammad Asaduzzaman
    Y1  - 2021/10/29
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ejpm.20210905.14
    DO  - 10.11648/j.ejpm.20210905.14
    T2  - European Journal of Preventive Medicine
    JF  - European Journal of Preventive Medicine
    JO  - European Journal of Preventive Medicine
    SP  - 133
    EP  - 139
    PB  - Science Publishing Group
    SN  - 2330-8230
    UR  - https://doi.org/10.11648/j.ejpm.20210905.14
    AB  - Background: On 8 March 2020 the first COVID-19 case was detected in Bangladesh. Day by day this disease is changing its own nature and dimension. So, it is very difficult to define the exact risk factors associated with such ferocious diseases. In this situation, haematological and biochemical analysis of COVID-19 patients may play an important role in the current and future planning of COVID treatment. Aim of the study: The aim of this study was to assess the COVID-19 status of Covid patients by haematological and biochemical markers. Materials and Methods: This prospective observational study was conducted among 350 participants who attended the Bashundhara Ad-Din Medical College Hospital, Hasnabad, South Keranigonj, Dhaka, Bangladesh after confirmation by RT-PCR. Using 5 ml fasting venous blood samples different haematological and biochemical biomarkers were analyzed. These were analyzed in auto analysis using a standard protocol as per the manufacturer’s instructions. Finally, results were analyzed using standard statistical calculation by% positivity, confidence interval, p values where p≤0.05 was considered as statistically significant. Results: In this study, in critical participant group, the mean (±SD) HBC, RBC, TLC, PCV, NLR, Platelet Counts, SGOT and SGPT were found 11.56±2.07, 3.64±2.82, 12372±2920, 29.17±7.84, 2.8±0.32, 98743±32127, 67.91±31.54 and 71.39±33.74 respectively. On the other hand, in non-critical patient group those reading were found 12.78±2.17, 4.02±2.90, 10956±2744, 35.03±8.22, 2.7±0.28, 129544±51228, 65.68±27.96 and 67.55±26.57 respectively. In analyzing the haematological and biochemical parameters among participants we found ‘extremely significant correlations’ between critical and non-critical groups in HBC, TLC, PCV, Platelet Counts, S. Creatinine and D-Dimer test results where p values were Conclusion: Haematological and biochemical markers may be considered as the most potential parameters in assessing the severity of COVID-19 infection. But, advanced training required for laboratory personnel’s who are responsible for collecting, transporting and handling biological samples and carrying out the various laboratory tests for patients with COVID-19 is recommended.
    VL  - 9
    IS  - 5
    ER  - 

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Author Information
  • Department of Medicine, Bashundhara Ad-Din Medical College Hospital, Dhaka, Bangladesh

  • Department of Medical Gastroenterology, Sheikh Russell National Gastroliver Institute & Hospital, Dhaka, Bangladesh

  • Department of Gastroenterology, Shaheed Suharawardy Medical College Hospital, Dhaka, Bangladesh

  • Department of Gastroenterology, Dhaka Medical College and Hospital, Dhaka, Bangladesh

  • Department of Gastroenterology, Sheikh Russell National Gastroliver Institute & Hospital, Dhaka, Bangladesh

  • Department of Hepatology, Mugda Medical College and Hospital, Dhaka, Bangladesh

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